Journal of Chronotherapy and Drug Delivery, Vol. 1

In pyridine all ring atoms, five carbons one nitrogen atoms, are sp2 hybridized. Two of the sp2 orbital’s on each atom overlap with each other to form the CC and C-N σ bond. The third sp2 orbital on each carbon atom overlaps with s orbital from hydrogen to form the C-H σ bonds; the third sp2 orbital on nitrogen is occupied by the nitrogen lone pair electrons. All σ bonds in pyridine lie in one plane. Pyridine shows some aromatic properties because the resulting molecular orbital satisfies the Huckel’s rule (n= 1 in 4n+2), according to the resonance theory pyridine is considered to be hybrid of the following five contributing structures.